Tg(Fabp4-Adipoq*)2Pesch
Transgene Detail

Summary

• Symbol: Tg(Fabp4-Adipoq*)2Pesch
• Name: transgene insertion 2, Philipp Scherer
• MGI ID: MGI:7539689
• Synonyms: deltaGLY-ADIPONECTIN
• Transgene: Tg(Fabp4-Adipoq*)2Pesch Location: unknown
• Alliance: Tg(Fabp4-Adipoq*)2Pesch page

Transgene origin

• Strain of Origin: FVB

Transgene description

• Transgene Type: Transgenic (Inserted expressed sequence)
• Mutation: Insertion
• Tg(Fabp4-Adipoq*)2Pesch expresses 1 gene
  Transgene expresses:
  

  Organism	Expressed Gene	Note
  mouse	Adipoq (MGI:106675)	encoding mouse adiponectin was altered by deleting the region encoding amino acids 5795, containing 13 collagen repeats

• Tg(Fabp4-Adipoq*)2Pesch expression driven by 1 gene
  Transgene expression driven by:
  

  Organism	Driver Gene	Note
  mouse	Fabp4 (MGI:88038)

• Mutation details: A cDNA containing the open reading frame encoding mouse adiponectin was altered by deleting the region encoding amino acids 5795, containing 13 collagen repeats. This deletion mutant lacks 13 of 22 Gly-X-Y repeats in the collagenous domain of the encoded protein. The mouse 5.4-kb aP2 enhancer/promoter sequence (Fabp4) was introduced upstream of the cDNA. In addition, the simian virus 40 splice and polyadenylase sequences were introduced into downstream of the cDNA. Multiple lines were generated, but line 2 had increased circulating levels in serum and was studied further. (J:87440)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available

References

• Original: J:87440 Combs TP, et al., A transgenic mouse with a deletion in the collagenous domain of adiponectin displays elevated circulating adiponectin and improved insulin sensitivity. Endocrinology. 2004 Jan;145(1):367-83
• All: 17 reference(s)