Tmem38b^tm1.1Afo
Targeted Allele Detail

Summary

• Symbol: Tmem38b^tm1.1Afo
• Name: transmembrane protein 38B; targeted mutation 1.1, Antonella Forlino
• MGI ID: MGI:7518723
• Synonyms: Tmem38b^fl
• Gene: Tmem38b Location: Chr4:53826045-53862019 bp, + strand Genetic Position: Chr4, 28.76 cM
• Alliance: Tmem38b^tm1.1Afo page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:338934
• Parent Cell Line: Not Specified (ES Cell)
• Strain of Origin: C57BL/6N

Mutation description

• Allele Type: Targeted (Conditional ready, No functional change)
• Mutation: Insertion
• Mutation details: A FRT site, lacZ, loxP site, neomycin selection cassette, FRT site, and loxP site were inserted upstream of exon 3 and a third loxP site was inserted downstream of exon 3. The lacZ and neomycin selection cassette were removed via flp-mediated recombination leaving exon 3 floxed. (J:338934)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Tmem38b Mutation: 52 strains or lines available

References

• Original: J:338934 Besio R, et al., CaMKII inhibition due to TRIC-B loss-of-function dysregulates SMAD signaling in osteogenesis imperfecta. Matrix Biol. 2023 Jun;120:43-59
• All: 1 reference(s)