Rr695546^tm1Hyku
Targeted Allele Detail

Summary

• Symbol: Rr695546^tm1Hyku
• Name: regulatory region 695546; targeted mutation 1, Hao Yuan Kueh
• MGI ID: MGI:7506597
• Synonyms: Bcl11b^tm2Hyku, Bcl11b^YFPdEnh
• Gene: Rr695546 Location: unknown Genetic Position: Chr12, Syntenic
• Alliance: Rr695546^tm1Hyku page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:290296
• Parent Cell Line: v6.5 (ES Cell)
• Strain of Origin: (C57BL/6 x 129S4/SvJae)F1

Mutation description

• Allele Type: Targeted (Modified regulatory region)
• Mutation: Insertion
• Mutation details: A 1.9 kb Bcl11b enhancer sequence, located ~752 kb downstream, was replaced with an FRT site flanked hygromycin resistance gene cassette in ES cells containing the Bcl11b^tm1.1Evr YFP reporter and Bcl11b^tm1Hyku mCherry reporter alleles. (J:290296)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Rr695546 Mutation: 0 strains or lines available

References

• Original: J:290296 Ng KK, et al., A stochastic epigenetic switch controls the dynamics of T-cell lineage commitment. Elife. 2018 Nov 20;7:e37851
• All: 3 reference(s)