Del(11Hnf1b-Znhit3)11Moro
Endonuclease-mediated Allele Detail

Summary

• Symbol: Del(11Hnf1b-Znhit3)11Moro
• Name: deletion, Chr 11, Eric Morrow
• MGI ID: MGI:7490277
• Synonyms: 17q12Del
• Gene: Del(11Hnf1b-Znhit3)11Moro Location: unknown Genetic Position: Chr11, Syntenic

Mutation origin

• Strain of Origin: C57BL/6

Mutation description

• Allele Type: Endonuclease-mediated (Null/knockout)
• Mutation: Intergenic deletion
• Del(11Hnf1b-Znhit3)11Moro involves 14 genes/genome features (Hnf1b, Ddx52, Synrg ...) View all
• Mutation details: CRISPR/cas9 genome editing is used to delete the 11qC region of the mouse genome between chr11:83791635-84938224 Mb [GRCm38.p6 (mm10), NCBI Reference Sequence, NC_000077.6]. The mouse deletion matches the consensus human deletion between chr17:31.8-33.2 Mb (GRCh38.p13, NCBI Reference Sequence, NC_000017.11). The 17q12 deletion removed all genes downstream of Gm11434 and upstream of Gm33028 including Aatf, Acaca, Gm11437, Ddx52, Dhrs11, Dusp14, Ggnbp2, Lhx1, Hnf1b, Mrm1, Myo19, Pigw, Synrg and Znhit3. sgRNAs were targeted to upstream of Hnf1b and downstream of Znhit3. (J:334297)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 1 strain available Cell Lines: 0 lines available
• Carrying any Del(11Hnf1b-Znhit3)11Moro Mutation: 1 strain or line available

References

• Original: J:334297 Warren EB, et al., 17q12 deletion syndrome mouse model shows defects in craniofacial, brain and kidney development, and glucose homeostasis. Dis Model Mech. 2022 Dec 1;15(12):dmm049752
• All: 1 reference(s)