Del(11Hnf1b-Znhit3)11Moro Cytogenetic Marker Detail

Summary

• Symbol
  Del(11Hnf1b-Znhit3)11Moro
• Name
  deletion, Chr 11, Eric Morrow

• Feature Type
  chromosomal deletion
• IDs
  MGI:7490276

Location &
Maps

• Sequence Map
  Genome coordinates not available from the current reference assembly.

• Genetic Map
  Chromosome 11, Syntenic

Human Diseases

• Diseases
  1 with Del(11Hnf1b-Znhit3)11Moro mouse models

Human Disease

Mouse Models

chromosome 17q12 deletion syndrome

IDs

chromosome 17q12 deletion syndrome      

DOID:0060404
ICD10CM:Q93.5
OMIM:614527
ORDO:261265

View 1 model

Mouse Models

Human Disease Modeled: chromosome 17q12 deletion syndrome

Allelic Composition	Genetic Background	Reference	Phenotypes
Del(11Hnf1b-Znhit3)11Moro/+	involves: C57BL/6N * CD-1	J:334297	View

Click on a disease name to see all genes associated with that disease.

• Mutations/Alleles
  1 with disease annotations

• References
  1 with disease annotations

Mutations,
Alleles, and
Phenotypes

• Phenotype Summary
  73 phenotypes from 1 allele in 2 genetic backgrounds
  1 phenotype reference
  

• All Mutations and Alleles
  1
• Endonuclease-mediated
  1
• Find Mice (IMSR)
  1 strains or lines available

Mice heterozygous for this deletion exhibit lethal abnormalities in head, craniofacial, and forebrain development on an inbred C57BL/6N background and similar, but less penetrant and milder, craniofacial and brain abnormalities on the outbred CD-1 background with additional defects in renal development and glucose homeostasis.

References

• Summaries
  All 2

  Diseases 1

  Phenotypes 1
• Earliest
  J:334297 Warren EB, et al., 17q12 deletion syndrome mouse model shows defects in craniofacial, brain and kidney development, and glucose homeostasis. Dis Model Mech. 2022 Dec 1;15(12):dmm049752