Eif5a2^em1Bach
Endonuclease-mediated Allele Detail

Summary

• Symbol: Eif5a2^em1Bach
• Name: eukaryotic translation initiation factor 5A2; endonuclease-mediated mutation 1, Andre Bachmann
• MGI ID: MGI:7468899
• Synonyms: eif5a2-K50R
• Gene: Eif5a2 Location: Chr3:28835426-28852995 bp, + strand Genetic Position: Chr3, 12.25 cM
• Alliance: Eif5a2^em1Bach page

Mutation origin

• Strain of Origin: 129X1/SvJ

Mutation description

• Allele Type: Endonuclease-mediated (Not Specified)
• Mutation: Nucleotide substitutions
• Mutation details: CRISPR-targeting of exon 2 introduced the mutation (AAG to CGA) responsible for the amino acid substitution lysine with arginine at position 50 (K50R). (J:335172)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 3 strains available Cell Lines: 0 lines available
• Carrying any Eif5a2 Mutation: 11 strains or lines available

References

• Original: J:335172 Schultz CR, et al., New K50R mutant mouse models reveal impaired hypusination of eif5a2 with alterations in cell metabolite landscape. Biol Open. 2023 Mar 15;12(3)
• All: 1 reference(s)