Ghsr^tm2.1Jmz
Targeted Allele Detail

Summary

• Symbol: Ghsr^tm2.1Jmz
• Name: growth hormone secretagogue receptor; targeted mutation 2.1, Jeffrey M Zigman
• MGI ID: MGI:7467199
• Synonyms: GHSR^fl
• Gene: Ghsr Location: Chr3:27425500-27432159 bp, + strand Genetic Position: Chr3, 10.86 cM
• Alliance: Ghsr^tm2.1Jmz page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:318685
• Parent Cell Line: SM1 (ES Cell)
• Strain of Origin: 129S6/SvEvTac

Mutation description

• Allele Type: Targeted (Conditional ready)
• Mutation: Insertion
• Mutation details: A targeting construct inserted a loxP at 256-bp upstream of the Ghsr start codon and a loxP-frt-Neo-frt cassette at 230-bp downstream of the Ghsr stop codon. An frt-flanked neomycin selection cassette was removed via flpe-mediated recombination. (J:318685)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Ghsr Mutation: 27 strains or lines available

References

• Original: J:318685 Gupta D, et al., Disrupting the ghrelin-growth hormone axis limits ghrelin's orexigenic but not glucoregulatory actions. Mol Metab. 2021 Nov;53:101258
• All: 2 reference(s)