Pgc^{tm1.1(cre/ERT2)Itoy}
Targeted Allele Detail

Summary

• Symbol: Pgc^{tm1.1(cre/ERT2)Itoy}
• Name: progastricsin (pepsinogen C); targeted mutation 1.1, Yoshiaki Ito
• MGI ID: MGI:7461847
• Synonyms: Pgc-CreERT2
• Gene: Pgc Location: Chr17:48037767-48045403 bp, + strand Genetic Position: Chr17, 23.98 cM, cytoband C
• Alliance: Pgc^{tm1.1(cre/ERT2)Itoy} page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:314694
• Parent Cell Line: Not Specified (ES Cell)
• Strain of Origin: Not Specified

Mutation description

• Allele Type: Targeted (Inducible, Recombinase, Reporter)
• Inducer: tamoxifen
• Mutation: Insertion
• Pgc^{tm1.1(cre/ERT2)Itoy} expression driven by 1 gene
  Knock-in expression driven by:
  

  Organism	Driver Gene	Note
  mouse	Pgc (MGI:98909)

• Mutation details: The mCherry-IRES-CreERT2-polyA sequence was inserted and replaced exon 1 of the Pgc gene after the start codon. The neo-selection cassette was removed subsequently. (J:314694)

Recombinase activity

Activity:	Tissue activity of this recombinase allele
Driver:	Pgc (mouse) Summary of all recombinase alleles driven by Pgc. Comparative matrix view of recombinase activities Alliance mouse Pgc gene page

Expression

In Mice Carrying this Mutation:

47 assay results

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Pgc Mutation: 19 strains or lines available

References

• Original: J:314694 Douchi D, et al., Induction of Gastric Cancer by Successive Oncogenic Activation in the Corpus. Gastroenterology. 2021 Dec;161(6):1907-1923.e26
• All: 1 reference(s)