Ppm1d^tm1.1Ble
Targeted Allele Detail

Summary

• Symbol: Ppm1d^tm1.1Ble
• Name: protein phosphatase 1D magnesium-dependent, delta isoform; targeted mutation 1.1, Benjamin Ebert
• MGI ID: MGI:7461271
• Synonyms: Ppm1d^fl
• Gene: Ppm1d Location: Chr11:85202080-85237897 bp, + strand Genetic Position: Chr11, 51.34 cM
• Alliance: Ppm1d^tm1.1Ble page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:343530
• Parent Cell Line: Not Specified (ES Cell)
• Strain of Origin: C57BL/6J x 129S6/SvEvTac

Mutation description

• Allele Type: Targeted (Conditional ready)
• Mutation: Insertion
• Mutation details: Exon 3 was flanked by loxP sites. The FRT site flanked neomycin resistance gene cassette that was inserted into intron 3 was removed through subsequent Flp-mediated recombination. (J:343530)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Ppm1d Mutation: 33 strains or lines available

References

• Original: J:343530 Miller PG, et al., PPM1D modulates hematopoietic cell fitness and response to DNA damage and is a therapeutic target in myeloid malignancy. Blood. 2023 Dec 14;142(24):2079-2091
• All: 1 reference(s)