Cpeb2^tm1.1Rme
Targeted Allele Detail

Summary

• Symbol: Cpeb2^tm1.1Rme
• Name: cytoplasmic polyadenylation element binding protein 2; targeted mutation 1.1, Raul Mendez
• MGI ID: MGI:7451389
• Synonyms: Cpeb2^lox
• Gene: Cpeb2 Location: Chr5:43390513-43447067 bp, + strand Genetic Position: Chr5, 23.65 cM, cytoband B
• Alliance: Cpeb2^tm1.1Rme page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:288987
• Parent Cell Line: G4 (ES Cell)
• Strain of Origin: (129S6/SvEvTac x C57BL/6NCrl)F1

Mutation description

• Allele Type: Targeted (Conditional ready)
• Mutation: Insertion
• Mutation details: The EUCOMM targeting vector PRPGS00036-W-3-B04 was used to create this conditional allele. The vector replaces exon 4 with an FRT site, lacZ sequence, loxP site, neomycin resistance gene under the control of the human beta-actin promoter, FRT site, and loxP-flanked exon 4. The lacZ and neomycin were removed via flp-mediated recombination in the ES cells leaving exon 4 floxed. (J:288987)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Cpeb2 Mutation: 36 strains or lines available

References

• Original: J:288987 Pascual R, et al., The RNA binding protein CPEB2 regulates hormone sensing in mammary gland development and luminal breast cancer. Sci Adv. 2020 May;6(20):eaax3868
• All: 1 reference(s)