Tead1^tm1Jusa
Targeted Allele Detail

Summary

• Symbol: Tead1^tm1Jusa
• Name: TEA domain family member 1; targeted mutation 1, Junichi Sadoshima
• MGI ID: MGI:7451292
• Synonyms: TEAD1^-
• Gene: Tead1 Location: Chr7:112278563-112505991 bp, + strand Genetic Position: Chr7, 58.8 cM, cytoband F2
• Alliance: Tead1^tm1Jusa page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:290188
• Parent Cell Line: Not Specified (ES Cell)
• Strain of Origin: Not Specified

Mutation description

• Allele Type: Targeted (Conditional ready, Null/knockout)
• Mutation: Insertion
• Mutation details: An 8954 bp fragment containing exon 3 and the alternatively spliced exon 4 (the DNA binding TEA domain) was used to insert loxP sites into the flanking introns. The recombined allele inadvertently also contains a duplicated exon 3. (J:290188)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Tead1 Mutation: 276 strains or lines available

References

• Original: J:290188 Ikeda S, et al., Hippo Deficiency Leads to Cardiac Dysfunction Accompanied by Cardiomyocyte Dedifferentiation During Pressure Overload. Circ Res. 2019 Jan 18;124(2):292-305
• All: 2 reference(s)