Wnt16^tm1.1Ohl
Targeted Allele Detail

Summary

• Symbol: Wnt16^tm1.1Ohl
• Name: wingless-type MMTV integration site family, member 16; targeted mutation 1.1, Claes Ohlsson
• MGI ID: MGI:7448937
• Synonyms: Wnt16^flox
• Gene: Wnt16 Location: Chr6:22288226-22298521 bp, + strand Genetic Position: Chr6, 9.22 cM, cytoband A3
• Alliance: Wnt16^tm1.1Ohl page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:227816
• Parent Cell Line: G4 (ES Cell)
• Strain of Origin: (129S6/SvEvTac x C57BL/6NCrl)F1

Mutation description

• Allele Type: Targeted (Conditional ready, No functional change)
• Mutation: Insertion
• Mutation details: EUCOMM targeting vector HTGRS6013_A_H08 was used to create this conditional-ready floxed allele. The vector places an FRT site, splice acceptor site, IRES, lacZ cassette, loxP site, neomycin resistance gene cassette, second FRT site and second loxP site upstream of exon 3 and a third loxP site downstream of exon 3. Flp-mediated recombination removed the lacZ and neomycin cassette leaving exon 3 floxed. (J:227816)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Wnt16 Mutation: 30 strains or lines available

References

• Original: J:227816 Moverare-Skrtic S, et al., Osteoblast-derived WNT16 represses osteoclastogenesis and prevents cortical bone fragility fractures. Nat Med. 2014 Nov;20(11):1279-88
• All: 3 reference(s)