Dapl1^em1Scs
Endonuclease-mediated Allele Detail

Summary

• Symbol: Dapl1^em1Scs
• Name: death associated protein-like 1; endonuclease-mediated mutation 1, Shao-Cong Sun
• MGI ID: MGI:7447447
• Gene: Dapl1 Location: Chr2:59314997-59335364 bp, + strand Genetic Position: Chr2, 33.81 cM, cytoband C3
• Alliance: Dapl1^em1Scs page

Mutation origin

• Strain of Origin: C57BL/6

Mutation description

• Allele Type: Endonuclease-mediated (Null/knockout)
• Mutation: Insertion
• Mutation details: CRISPR/Cas9 technology introduced a stop codon (TAA) and an EcoRI restriction site (GAATTC) to the 3 boundary of exon 3. (J:333979)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Dapl1 Mutation: 11 strains or lines available

References

• Original: J:333979 Zhu L, et al., Dapl1 controls NFATc2 activation to regulate CD8(+) T cell exhaustion and responses in chronic infection and cancer. Nat Cell Biol. 2022 Jul;24(7):1165-1176
• All: 1 reference(s)