Oasl1tm1c(EUCOMM)Hmgu
Targeted Allele Detail
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Symbol: |
Oasl1tm1c(EUCOMM)Hmgu |
Name: |
2'-5' oligoadenylate synthetase-like 1; targeted mutation 1c, Helmholtz Zentrum Muenchen GmbH |
MGI ID: |
MGI:7442585 |
Synonyms: |
Oasl1fl |
Gene: |
Oasl1 Location: Chr5:115061299-115075974 bp, + strand Genetic Position: Chr5, 55.99 cM
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Alliance: |
Oasl1tm1c(EUCOMM)Hmgu page
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IMPC: |
Oasl1 gene page |
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Germline Transmission: |
Earliest citation of germline transmission:
J:333834
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Parent Cell Line: |
JM8A1.N3 (ES Cell)
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Strain of Origin: |
C57BL/6N-Atm1Brd
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Project Collection: |
EUCOMM
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Allele Type: |
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Targeted (Conditional ready) |
Mutation: |
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Insertion
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Mutation details: The L1L2_Bact_P cassette was inserted at position 115065658 of Chromosome 5 upstream of the critical exon(s) (Build GRCm39). The cassette is composed of an FRT site followed by lacZ sequence and a loxP site. This first loxP site is followed by a neomycin resistance gene under the control of the human beta-actin promoter, SV40 polyA, a second FRT site and a second loxP site. A third loxP site is inserted downstream of the targeted exon(s) at position 115066612. The critical exon(s) is/are thus flanked by loxP sites. A "conditional ready" (floxed) allele was created by flp recombinase expression in mice carrying this allele to remove the lacZ sequence and neo selection cassette, leaving loxP sites flanking the critical exon(s). Further information on targeting strategies used for this and other IKMC alleles can be found at http://www.informatics.jax.org/mgihome/nomen/IKMC_schematics.shtml
(J:333834)
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Mouse strains and cell lines
available from the International Mouse Strain Resource
(IMSR) |
Carrying this Mutation: |
Mouse Strains: 0 strains available
Cell Lines: 0 lines available
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Carrying any Oasl1 Mutation: |
33 strains or lines available
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Original: |
J:333834 Kim TK, et al., 2'-5' oligoadenylate synthetaselike 1 (OASL1) protects against atherosclerosis by maintaining endothelial nitric oxide synthase mRNA stability. Nat Commun. 2022 Nov 4;13(1):6647 |
All: |
1 reference(s) |
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