F2rl1^em2Wmrf
Endonuclease-mediated Allele Detail

Summary

• Symbol: F2rl1^em2Wmrf
• Name: F2R like trypsin receptor 1; endonuclease-mediated mutation 2, Wolfram Ruf
• MGI ID: MGI:7434623
• Synonyms: F2rl1^em2Ruf, PAR2 S365A/T368A
• Gene: F2rl1 Location: Chr13:95648240-95661735 bp, - strand Genetic Position: Chr13, 49.53 cM
• Alliance: F2rl1^em2Wmrf page

Mutation origin

• Strain of Origin: C57BL/6N

Mutation description

• Allele Type: Endonuclease-mediated (Not Applicable)
• Mutation: Nucleotide substitutions
• Mutation details: Serine codon 365 (AGT) and threonine codon 368 (ACT) in exon 2 were changed to alanine (GCG) (p.S365A, p.T368A) using an sgRNA and an ssODN template with CRISPR/Cas9 technology. The mutations block phosphorylation of the residues in the encoded peptide. (J:277231)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any F2rl1 Mutation: 60 strains or lines available

References

• Original: J:277231 Wolfram R, F2rl1 Direct Data Submission. MGI Direct Data Submission. 2019
• All: 1 reference(s)