Rr353^tm1.1Drhi
Targeted Allele Detail

Summary

• Symbol: Rr353^tm1.1Drhi
• Name: regulatory region 353; targeted mutation 1.1, Douglas R Higgs
• MGI ID: MGI:7433177
• Synonyms: delta R4
• Gene: Rr353 Location: unknown Genetic Position: Chr11, Syntenic
• Alliance: Rr353^tm1.1Drhi page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:259286
• Parent Cell Line: E14TG2a (ES Cell)
• Strain of Origin: 129P2/OlaHsd

Mutation description

• Allele Type: Targeted (Modified regulatory region)
• Mutations: Insertion, Intergenic deletion
• Mutation details: Hba enhancer element R4 upstream of Nprl3 was replaced with a loxP site flanked neomycin resistance gene cassette. The neo cassette was removed through subsequent cre-mediated recombination. (J:259286)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Rr353 Mutation: 0 strains or lines available

References

• Original: J:259286 Hay D, et al., Genetic dissection of the alpha-globin super-enhancer in vivo. Nat Genet. 2016 Aug;48(8):895-903
• All: 1 reference(s)