Rr351^tm3.1Drhi
Targeted Allele Detail

Summary

• Symbol: Rr351^tm3.1Drhi
• Name: regulatory region 351; targeted mutation 3.1, Douglas R Higgs
• MGI ID: MGI:7433171
• Synonyms: delta R3
• Gene: Rr351 Location: Chr11:32206068-32206646 bp Genetic Position: Chr11, Syntenic
• Alliance: Rr351^tm3.1Drhi page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:259286
• Parent Cell Line: E14TG2a (ES Cell)
• Strain of Origin: 129P2/OlaHsd

Mutation description

• Allele Type: Targeted (Modified regulatory region)
• Mutations: Insertion, Intragenic deletion
• Mutation details: Hba enhancer element R3 in Nprl3 intron 2 was replaced with a loxP site flanked neomycin resistance gene cassette. The neo cassette was removed through subsequent cre-mediated recombination. (J:259286)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Rr351 Mutation: 0 strains or lines available

References

• Original: J:259286 Hay D, et al., Genetic dissection of the alpha-globin super-enhancer in vivo. Nat Genet. 2016 Aug;48(8):895-903
• All: 1 reference(s)