Dock8^tm1.1Geha
Targeted Allele Detail

Summary

• Symbol: Dock8^tm1.1Geha
• Name: dedicator of cytokinesis 8; targeted mutation 1.1, Raif S Geha
• MGI ID: MGI:7432967
• Synonyms: Dock8^flox
• Gene: Dock8 Location: Chr19:24976898-25179796 bp, + strand Genetic Position: Chr19, 19.91 cM
• Alliance: Dock8^tm1.1Geha page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:287897
• Parent Cell Line: Not Specified (ES Cell)
• Strain of Origin: 129

Mutation description

• Allele Type: Targeted (Conditional ready, No functional change)
• Mutation: Insertion
• Mutation details: A loxP site and FRT-flanked neomycin gene were inserted upstream of exon 44 and a second loxP site was inserted downstream of exon 46. The neomycin gene was removed via flp-mediated recombination leaving exons 44-46 floxed. (J:287897)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 1 strain available Cell Lines: 0 lines available
• Carrying any Dock8 Mutation: 103 strains or lines available

References

• Original: J:287897 Janssen E, et al., DOCK8 enforces immunological tolerance by promoting IL-2 signaling and immune synapse formation in Tregs. JCI Insight. 2017 Oct 5;2(19)
• All: 2 reference(s)