Myh9^{tm1.1(Myh14*/GFP)Maxu}
Targeted Allele Detail

Summary

• Symbol: Myh9^{tm1.1(Myh14*/GFP)Maxu}
• Name: myosin, heavy polypeptide 9, non-muscle; targeted mutation 1.1, Xuefei Ma
• MGI ID: MGI:7432903
• Synonyms: A^C1*gfp
• Gene: Myh9 Location: Chr15:77644788-77726315 bp, - strand Genetic Position: Chr15, 36.81 cM
• Alliance: Myh9^{tm1.1(Myh14*/GFP)Maxu} page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:317371
• Parent Cell Line: Not Specified (ES Cell)
• Strain of Origin: 129

Mutation description

• Allele Type: Targeted (Inserted expressed sequence, Null/knockout, Reporter)
• Mutation: Insertion
• Myh9^{tm1.1(Myh14*/GFP)Maxu} expresses 1 gene
  Knock-in expresses:
  

  Organism	Expressed Gene	Note
  mouse	Myh14 (MGI:1919210)	The C1 isoform fused to GFP is expressed

• Mutation details: A construct containing a cDNA for the mouse Myh14 C1 isoform fused to GFP, a poly-A sequence, and a floxed neo cassette was inserted in exon 2 just 5' of the initiating codon via homologous recombination. Cre mediated recombination removed the neo cassette. (J:317371)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Myh9 Mutation: 221 strains or lines available

References

• Original: J:317371 Zhang Y, et al., Replacing nonmuscle myosin 2A with myosin 2C1 permits gastrulation but not placenta vascular development in mice. Mol Biol Cell. 2018 Sep 15;29(19):2326-2335
• All: 1 reference(s)