Zdhhc12^em1Cya
Endonuclease-mediated Allele Detail

Summary

• Symbol: Zdhhc12^em1Cya
• Name: zinc finger, DHHC domain containing 12; endonuclease-mediated mutation 1, Cyagen Biosciences
• MGI ID: MGI:7431133
• Synonyms: Zdhhc12^-
• Gene: Zdhhc12 Location: Chr2:29980956-29983647 bp, - strand Genetic Position: Chr2, 21.15 cM, cytoband B
• Alliance: Zdhhc12^em1Cya page

Mutation origin

• Strain of Origin: C57BL/6NCya

Mutation description

• Allele Type: Endonuclease-mediated (Null/knockout)
• Mutation: Not Specified
• Mutation details: CRISPR-targeting the fragment for Zdhhc12+/- guide RNA (gRNA) (gRNA1, matching reverse strand of the gene, 5'-ACAAAGGGCAAAAGCGATGGAGG-3'; gRNA2, matching forward strand of gene, 5'- ACATCACCCAAGACCCATGTGGG-30' was injected into zygotes of C57BL/6 WT mice. (J:332897)

Expression

In Structures Affected by this Mutation:

1 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Zdhhc12 Mutation: 19 strains or lines available

References

• Original: J:332897 Wang L, et al., Palmitoylation prevents sustained inflammation by limiting NLRP3 inflammasome activation through chaperone-mediated autophagy. Mol Cell. 2023 Jan 19;83(2):281-297.e10
• All: 2 reference(s)