Phenotypes associated with this allele

• Allele Symbol: Zdhhc12^em1Cya
• Allele Name: endonuclease-mediated mutation 1, Cyagen Biosciences
• Allele ID: MGI:7431133
• Summary: 1 genotype

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	Zdhhc12^em1Cya/Zdhhc12^em1Cya	C57BL/6NCya-Zdhhc12^em1Cya	MGI:8276691

Genotype
MGI:8276691

hm1

• Allelic Composition: Zdhhc12^em1Cya/Zdhhc12^em1Cya
• Genetic Background: C57BL/6NCya-Zdhhc12^em1Cya

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

immune system

increased neutrophil cell number ( J:332897 )

• increase in alum-triggered recruitment of CD11b+ Ly6G+ neutrophils to lavage fluids compared to treatment matched wild-type controls

increased interleukin level ( J:332897 )

• elevated IL1B levels in peritoneal lavage fluids following alum challenge compared to treatment matched wild-type mice

increased circulating interleukin-1 beta level ( J:332897 )

• in the plasma following LPS challenge

• elevated IL1Blevels are seen 14 to 42 days after LPS challenge unlike in similarly treated wild-type controls where levels return to normal after 14 days

increased susceptibility to endotoxin shock ( J:332897 )

• show more severe lung damage, increased inflammatory cell infiltration, alveolar edema and hemorrhage, septal hemorrhage, and congestion, following LPS challenge

• increased overall acute lung injury score following LPS challenge

• increase in LPS-triggered lymphocytes, macrophages, and neutrophils in bronchoalveolar lavage fluids

• at a lethal dose mice show higher susceptibility to endotoxic shock

hematopoietic system

increased neutrophil cell number ( J:332897 )

• increase in alum-triggered recruitment of CD11b+ Ly6G+ neutrophils to lavage fluids compared to treatment matched wild-type controls

homeostasis/metabolism

increased interleukin level ( J:332897 )

• elevated IL1B levels in peritoneal lavage fluids following alum challenge compared to treatment matched wild-type mice

increased protein level ( J:332897 )

• increased NLRP3 levels and GSDMD activation in peritoneal exudate cells

increased circulating interleukin-1 beta level ( J:332897 )

• in the plasma following LPS challenge

• elevated IL1Blevels are seen 14 to 42 days after LPS challenge unlike in similarly treated wild-type controls where levels return to normal after 14 days