Kcnj13^tm1.1Jfhe
Targeted Allele Detail

Summary

• Symbol: Kcnj13^tm1.1Jfhe
• Name: potassium inwardly-rectifying channel, subfamily J, member 13; targeted mutation 1.1, J Fielding Hejtmancik
• MGI ID: MGI:7429021
• Gene: Kcnj13 Location: Chr1:87314085-87322451 bp, - strand Genetic Position: Chr1, 44.3 cM
• Alliance: Kcnj13^tm1.1Jfhe page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:319656
• Parent Cell Line: R1 (ES Cell)
• Strain of Origin: (129X1/SvJ x 129S1/Sv)F1-Kitl⁺

Mutation description

• Allele Type: Targeted (Conditional ready)
• Mutation: Insertion
• Mutation details: A construct containing an FRT site, splice acceptor, IRES, beta-gal gene, loxP site, PGK-neo cassette, FRT site, and loxP site was inserted upstream of exon 2 and a third loxP site was inserted downstream of exon 2 via homologous recombination. Flp mediated recombination removed the bet-gal and neo cassettes leaving exon 2 floxed. (J:319656)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Kcnj13 Mutation: 23 strains or lines available

References

• Original: J:319656 Jiao X, et al., Retinal Development and Pathophysiology in Kcnj13 Knockout Mice. Front Cell Dev Biol. 2021;9:810020
• All: 1 reference(s)