Taar1^tm1Blt
Targeted Allele Detail

Summary

• Symbol: Taar1^tm1Blt
• Name: trace amine-associated receptor 1; targeted mutation 1, Horst Bluethmann
• MGI ID: MGI:7428315
• Synonyms: Taar1^{tm1(NLSLacZ)Blt}
• Gene: Taar1 Location: Chr10:23796304-23797302 bp, + strand Genetic Position: Chr10, 11.39 cM, cytoband A3
• Alliance: Taar1^tm1Blt page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:279201
• Parent Cell Line: Not Specified (ES Cell)
• Strain of Origin: C57BL/6

Mutation description

• Allele Type: Targeted (Null/knockout, Reporter)
• Mutations: Insertion, Intragenic deletion
• Mutation details: A lacZ coding sequence fused to a nuclear localization sequence (NLS), a PGK-neomycin resistance gene, and a diphtheria toxin cassette replaced the coding sequence and was fused in frame with the endogenous Taar1 start codon. RT-PCR confirmed absence of transcript in brain and expression of LacZ transcript. (J:279201)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Taar1 Mutation: 31 strains or lines available

References

• Original: J:279201 Lindemann L, et al., Trace amine-associated receptor 1 modulates dopaminergic activity. J Pharmacol Exp Ther. 2008 Mar;324(3):948-56
• All: 2 reference(s)