Cpe^tm1Fril
Targeted Allele Detail

Summary

• Symbol: Cpe^tm1Fril
• Name: carboxypeptidase E; targeted mutation 1, Lloyd D Fricker
• MGI ID: MGI:7414194
• Synonyms: CpeNeo
• Gene: Cpe Location: Chr8:65045576-65146088 bp, - strand Genetic Position: Chr8, 32.3 cM
• Alliance: Cpe^tm1Fril page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:324731
• Parent Cell Line: R1 (ES Cell)
• Strain of Origin: (129X1/SvJ x 129S1/Sv)F1-Kitl⁺

Mutation description

• Allele Type: Targeted (Conditional ready, Null/knockout)
• Mutation: Insertion
• Mutation details: A loxP site and FRT flanked neo cassette were inserted 286 bp 5' of exon 4 and a second loxP site was inserted 736 bp 3' of exon 5 via homologous recombination.Assays of enzymatic activity and mRNA levels indicate near total loss of function. (J:324731)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Cpe Mutation: 26 strains or lines available

References

• Original: J:324731 Fricker LD, et al., Neuropeptidomic Analysis of a Genetically Defined Cell Type in Mouse Brain and Pituitary. Cell Chem Biol. 2021 Jan 21;28(1):105-112.e4
• All: 2 reference(s)