Dp(15Rr38-Asap1)5Fsp
Transposon induced Allele Detail

Summary

• Symbol: Dp(15Rr38-Asap1)5Fsp
• Name: duplication, Chr 15, Francois Spitz 5
• MGI ID: MGI:7411370
• Synonyms: dup(8-21)
• Gene: Dp(15Rr38-Asap1)5Fsp Location: unknown Genetic Position: Chr15, Syntenic

Mutation origin

• Strain of Origin: Not Applicable

Mutation description

• Allele Type: Transposon induced (Conditional ready, Modified regulatory region, Reporter)
• Mutation: Duplication
• Dp(15Rr38-Asap1)5Fsp involves 39 genes/genome features (Gm49019, Rr334, Gm30113 ...) View all
• Mutation details: Cre-mediated inter-chromosomal recombination between Tn(sb-SBlac)15.190909Fsp at chr15:62708797-62708798 (GRCm39) and Tn(sb-SBlac)15.180206Fsp at chr15:63982993-63982994 duplicated approximately 1.27 Mb and leaves one intact copy of the transposon cassette (in reverse orientation) at the duplication junction. The transposon consists of a Sleeping Beauty transposon inverted repeat, loxP site, human beta-globin HBB minimal promoter, the lacZ beta-galactosidase reporter gene, SV40 poly(A) signal sequence, and a Sleeping Beauty transposon direct repeat. The centromeric part of the deleted sequence is part of the Myc topologically associating domain (TAD) and the deletion deletes Myc enhancers Rr38, Rr334, Rr316124, Rr313933, Rr331, Rr307328, Rr332, Rr307330, Rr333, Rr313939 and Rr313944, the Gsdmc gene cluster, Cyrib and the 3' end of Asap1. (J:212391)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Dp(15Rr38-Asap1)5Fsp Mutation: 0 strains or lines available

References

• Original: J:212391 Uslu VV, et al., Long-range enhancers regulating Myc expression are required for normal facial morphogenesis. Nat Genet. 2014 Jul;46(7):753-8
• All: 1 reference(s)