Notum^tm1.1Geno
Targeted Allele Detail

Summary

• Symbol: Notum^tm1.1Geno
• Name: notum palmitoleoyl-protein carboxylesterase; targeted mutation 1.1, Genoway
• MGI ID: MGI:7410815
• Synonyms: Notum^c
• Gene: Notum Location: Chr11:120544614-120552001 bp, - strand Genetic Position: Chr11, 84.38 cM
• Alliance: Notum^tm1.1Geno page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:325755
• Parent Cell Line: Not Specified (ES Cell)
• Strain of Origin: C57BL/6

Mutation description

• Allele Type: Targeted (Conditional ready, No functional change)
• Mutation: Insertion
• Mutation details: Exon 8 was flanked by loxP sites. An inserted FRT-flanked neomycin selection cassette was removed via flp-mediated recombination. (J:325755)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Notum Mutation: 30 strains or lines available

References

• Original: J:325755 Flanagan DJ, et al., NOTUM from Apc-mutant cells biases clonal competition to initiate cancer. Nature. 2021 Jun;594(7863):430-435
• All: 1 reference(s)