Arhgef26^em2Pte
Endonuclease-mediated Allele Detail

Summary

• Symbol: Arhgef26^em2Pte
• Name: Rho guanine nucleotide exchange factor 26; endonuclease-mediated mutation 2, Patrick Ellinor
• MGI ID: MGI:7398534
• Synonyms: Arhgef26 KO
• Gene: Arhgef26 Location: Chr3:62245765-62369642 bp, + strand Genetic Position: Chr3, 29.97 cM
• Alliance: Arhgef26^em2Pte page

Mutation origin

• Strain of Origin: C57BL/6J

Mutation description

• Allele Type: Endonuclease-mediated (Null/knockout)
• Mutation: Intragenic deletion
• Mutation details: CRISPR/cas9 genome editing intended to insert loxP sequences on either side of exon 5 resulted in the deletion of exon 5. (J:331761)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Arhgef26 Mutation: 49 strains or lines available

References

• Original: J:331761 Zhu QM, et al., Endothelial ARHGEF26 is an angiogenic factor promoting VEGF signalling. Cardiovasc Res. 2022 Oct 21;118(13):2833-2846
• All: 1 reference(s)