Ndrg3^{tm1c(KOMP)Wtsi}
Targeted Allele Detail

Summary

• Symbol: Ndrg3^{tm1c(KOMP)Wtsi}
• Name: N-myc downstream regulated gene 3; targeted mutation 1c, Wellcome Trust Sanger Institute
• MGI ID: MGI:7398102
• Synonyms: Ndrg3^f
• Gene: Ndrg3 Location: Chr2:156769265-156833976 bp, - strand Genetic Position: Chr2, 77.89 cM
• Alliance: Ndrg3^{tm1c(KOMP)Wtsi} page
• IMPC: Ndrg3 gene page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:330551
• Parent Cell Line: JM8.N4 (ES Cell)
• Strain of Origin: C57BL/6N
• Project Collection: KOMP-CSD

Mutation description

• Allele Type: Targeted (Conditional ready)
• Mutation: Insertion
• Mutation details: The L1L2_gt0 cassette was inserted at position 156791669 of Chromosome 2 upstream of the critical exon 4 (Build GRCm39). The cassette is composed of an FRT flanked lacZ/neomycin sequence followed by a loxP site. An additional loxP site is inserted downstream of the targeted exon 4 at position 156792496. The critical exon 4 is thus flanked by loxP sites. The lacZ/neomycin were removed via flp-mediated recombination generating a conditional ready exon 4 floxed allele. (J:330551)

Expression

In Mice Carrying this Mutation:

1 RNA-Seq or microarray experiment(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Ndrg3 Mutation: 44 strains or lines available

References

• Original: J:330551 Sohn HA, et al., Glycogen Storage Disease Phenotypes Accompanying the Perturbation of the Methionine Cycle in NDRG3-Deficient Mouse Livers. Cells. 2022 May 4;11(9)
• All: 3 reference(s)