Rr308^{tm3.1(Rr299391)Fwa}
Targeted Allele Detail

Summary

• Symbol: Rr308^{tm3.1(Rr299391)Fwa}
• Name: regulatory region 308; targeted mutation 3.1, Frederick W Alt
• MGI ID: MGI:7386901
• Synonyms: EdeltaR
• Gene: Rr308 Location: unknown Genetic Position: Chr14, Syntenic
• Alliance: Rr308^{tm3.1(Rr299391)Fwa} page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:82395
• Parent Cell Line: TC1/TC-1 (ES Cell)
• Strain of Origin: 129S6/SvEvTac

Mutation description

• Allele Type: Targeted (Modified regulatory region)
• Mutations: Insertion, Intergenic deletion
• Mutation details: A 1 kb PvuII-BamHI genomic fragment containing Tcra enhancer Ealpha was replaced with a sequence containing a loxP site flanked neomycin resistance gene cassette and Tcrd enhancer Edelta (Rr299391). The neo cassette was subsequently deleted through cre-mediated recombination. (J:82395)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Rr308 Mutation: 0 strains or lines available

References

• Original: J:82395 Bassing CH, et al., T cell receptor (TCR) alpha/delta locus enhancer identity and position are critical for the assembly of TCR delta and alpha variable region genes. Proc Natl Acad Sci U S A. 2003 Mar 4;100(5):2598-603
• All: 1 reference(s)