Rr311^em1Bhao
Endonuclease-mediated Allele Detail

Summary

• Symbol: Rr311^em1Bhao
• Name: regulatory region 311; endonuclease-mediated mutation 1, Bingtao Hao
• MGI ID: MGI:7378556
• Synonyms: EACBE^-
• Gene: Rr311 Location: Chr14:54465538-54465774 bp Genetic Position: Chr14, Syntenic
• Alliance: Rr311^em1Bhao page

Mutation origin

• Strain of Origin: C57BL/6

Mutation description

• Allele Type: Endonuclease-mediated (Modified regulatory region)
• Mutation: Intergenic deletion
• Mutation details: Trca enhancer Rr308-associated CTCF binding site was targeted with sgRNAs using CRISPR/Cas9 technology, resulting in a 197 bp deletion. (J:296383)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Rr311 Mutation: 0 strains or lines available

References

• Original: J:296383 Zhao H, et al., A role of the CTCF binding site at enhancer Ealpha in the dynamic chromatin organization of the Tcra-Tcrd locus. Nucleic Acids Res. 2020 Sep 25;48(17):9621-9636
• All: 2 reference(s)