Rorc^tm1Cdon
Targeted Allele Detail

Summary

• Symbol: Rorc^tm1Cdon
• Name: RAR-related orphan receptor gamma; targeted mutation 1, Chen Dong
• MGI ID: MGI:7367592
• Synonyms: Rorc^fl, RORgamma^fl
• Gene: Rorc Location: Chr3:94280106-94305583 bp, + strand Genetic Position: Chr3, 40.56 cM, cytoband F2
• Alliance: Rorc^tm1Cdon page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:254230
• Parent Cell Line: Not Specified (ES Cell)
• Strain of Origin: Not Specified

Mutation description

• Allele Type: Targeted (Conditional ready, No functional change)
• Mutation: Insertion
• Mutation details: A loxP site was inserted into intron 1 and a second loxP site into intron 3. The FRT site flanked neomycin resistance gene cassette that was also inserted was removed through subsequent flp-mediated recombination, leaving a conditional-ready allele with exons 2 and 3 floxed. (J:254230)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Rorc Mutation: 42 strains or lines available

References

• Original: J:254230 Kim BS, et al., Generation of RORgammat(+) Antigen-Specific T Regulatory 17 Cells from Foxp3(+) Precursors in Autoimmunity. Cell Rep. 2017 Oct 3;21(1):195-207
• All: 2 reference(s)