F2rl1^tm3.2Wmrf
Targeted Allele Detail

Summary

• Symbol: F2rl1^tm3.2Wmrf
• Name: F2R like trypsin receptor 1; targeted mutation 3.2, Wolfram Ruf
• MGI ID: MGI:7335947
• Synonyms: F2rl1^tm3.2Ruf, PAR2^-
• Gene: F2rl1 Location: Chr13:95648240-95661735 bp, - strand Genetic Position: Chr13, 49.53 cM
• Alliance: F2rl1^tm3.2Wmrf page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:328121
• Parent Cell Line: C2 (Nagy) (ES Cell)
• Strain of Origin: C57BL/6NTac

Mutation description

• Allele Type: Targeted (Null/knockout)
• Mutations: Insertion, Intragenic deletion
• Mutation details: LoxP sites were inserted into intron 1 and 3' of WT exon 2. An FRT site flanked selection cassette that was inserted was removed via subsequent Flp-mediated recombination. Cre-mediated recombination deleted the floxed region. (J:328121)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any F2rl1 Mutation: 60 strains or lines available

References

• Original: J:328121 Bochenek ML, et al., EPCR-PAR1 biased signaling regulates perfusion recovery and neovascularization in peripheral ischemia. JCI Insight. 2022 Jul 22;7(14):e157701
• All: 1 reference(s)