Arhgap11a^em1Wbh
Endonuclease-mediated Allele Detail

Summary

• Symbol: Arhgap11a^em1Wbh
• Name: Rho GTPase activating protein 11A; endonuclease-mediated mutation 1, Wieland B Huttner
• MGI ID: MGI:7328428
• Synonyms: 11A^-
• Gene: Arhgap11a Location: Chr2:113661837-113679006 bp, - strand Genetic Position: Chr2, 57.47 cM
• Alliance: Arhgap11a^em1Wbh page

Mutation origin

• Strain of Origin: Not Specified

Mutation description

• Allele Type: Endonuclease-mediated (Null/knockout)
• Mutations: Insertion, Intragenic deletion
• Mutation details: CRISPR/Cas9 technology introduced a premature stop codon in exon 1, 75 nucleotides downstream of the start codon, by replacing nucleotides CCGCG with TTA. (J:308527)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Arhgap11a Mutation: 39 strains or lines available

References

• Original: J:308527 Xing L, et al., Expression of human-specific ARHGAP11B in mice leads to neocortex expansion and increased memory flexibility. EMBO J. 2021 Jul 1;40(13):e107093
• All: 1 reference(s)