Vps35^tm1.1Smsa
Targeted Allele Detail

Summary

• Symbol: Vps35^tm1.1Smsa
• Name: VPS35 retromer complex component; targeted mutation 1.1, Scott A Small
• MGI ID: MGI:7327653
• Synonyms: Vps35^fl
• Gene: Vps35 Location: Chr8:85987014-86026146 bp, - strand Genetic Position: Chr8, 41.61 cM
• Alliance: Vps35^tm1.1Smsa page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:299250
• Parent Cell Line: Not Specified (ES Cell)
• Strain of Origin: Not Specified

Mutation description

• Allele Type: Targeted (Conditional ready)
• Mutation: Insertion
• Mutation details: Exons 3 to 5 were floxed and an FRT flanked neo cassette was inserted via homologous recombination. Flp mediated recombination removed the neo cassette. (J:299250)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Vps35 Mutation: 43 strains or lines available

References

• Original: J:299250 Simoes S, et al., Tau and other proteins found in Alzheimer's disease spinal fluid are linked to retromer-mediated endosomal traffic in mice and humans. Sci Transl Med. 2020 Nov 25;12(571)
• All: 3 reference(s)