Rr206^tm1.1Jmb
Targeted Allele Detail

Summary

• Symbol: Rr206^tm1.1Jmb
• Name: regulatory region 206; targeted mutation 1.1, Jeremy M Boss
• MGI ID: MGI:7316692
• Synonyms: deltaC15
• Gene: Rr206 Location: Chr17:34498053-34539132 bp Genetic Position: Chr17, Syntenic
• Alliance: Rr206^tm1.1Jmb page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:320461
• Parent Cell Line: Not Specified (ES Cell)
• Strain of Origin: Not Specified

Mutation description

• Allele Type: Targeted (Modified regulatory region)
• Mutations: Insertion, Intergenic deletion
• Mutation details: A loxP site was inserted downstream of CTCF-binding site C15 in the IA/IE-SE super enhancer between H2-Eb1 and H2-Aa, and a second loxP site and an FRT site flanked neomycin resistance gene cassette upstream. The C15 sequence and neo cassette were deleted through subsequent cre-mediated recombination. (J:320461)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Rr206 Mutation: 0 strains or lines available

References

• Original: J:320461 Majumder P, et al., The Murine MHC Class II Super Enhancer IA/IE-SE Contains a Functionally Redundant CTCF-Binding Component and a Novel Element Critical for Maximal Expression. J Immunol. 2021 May 1;206(9):2221-2232
• All: 1 reference(s)