Wwc2^tm1.1Fxyu
Targeted Allele Detail

Summary

• Symbol: Wwc2^tm1.1Fxyu
• Name: WW, C2 and coiled-coil domain containing 2; targeted mutation 1.1, Fa-Xing Yu
• MGI ID: MGI:7314960
• Synonyms: Wwc2^F
• Gene: Wwc2 Location: Chr8:48279117-48443579 bp, - strand Genetic Position: Chr8, 26.91 cM
• Alliance: Wwc2^tm1.1Fxyu page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:325475
• Parent Cell Line: Not Specified (ES Cell)
• Strain of Origin: Not Specified

Mutation description

• Allele Type: Targeted (Conditional ready, No functional change)
• Mutation: Insertion
• Mutation details: The targeting construct introduced a loxP site upstream of exon 2 and an Rox-flanked neomycin resistance cassette with a 3 prime loxP site. Dre-mediated recombination removed the selection cassette. (J:325475)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Wwc2 Mutation: 69 strains or lines available

References

• Original: J:325475 Qi S, et al., WWC proteins mediate LATS1/2 activation by Hippo kinases and imply a tumor suppression strategy. Mol Cell. 2022 May 19;82(10):1850-1864.e7
• All: 3 reference(s)