Igs2^{em13(Alb-TTR*V50M)Gpt}
Endonuclease-mediated Allele Detail

Summary

• Symbol: Igs2^{em13(Alb-TTR*V50M)Gpt}
• Name: intergenic site 2; endonuclease-mediated mutation 13, GemPharmatech Co., Ltd
• MGI ID: MGI:7300626
• Synonyms: Igs2^{em1Cin(Alb- hTTR V50M luciferase)}
• Gene: Igs2 Location: Chr11:3195460-3195497 bp Genetic Position: Chr11, Syntenic
• Alliance: Igs2^{em13(Alb-TTR*V50M)Gpt} page

Mutation origin

• Strain of Origin: C57BL/6JGpt

Mutation description

• Allele Type: Endonuclease-mediated (Humanized sequence, Inserted expressed sequence, Reporter)
• Mutation: Insertion
• Igs2^{em13(Alb-TTR*V50M)Gpt} expresses 1 gene
  Knock-in expresses:
  

  Organism

  Expressed Gene

  Homolog in Mouse

  Note

  human

  TTR (7276)

  Ttr	(MGI:98865)

• Mutation details: CRISPR-targeting inserted the mouse promoter driving liver-specific expression of the human gene coding sequence with a mutation that results in the amino acid substitution of valine with methionine at position 50 (V50M). A luciferase reporter gene was also inserted into the locus. (J:293217)
• Inheritance: Not Specified

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Igs2 Mutation: 69 strains or lines available

References

• Original: J:293217 GemPharmatech, GemPharmatech Website. 2020
• All: 1 reference(s)