Cacnb2^tm1.1Hfm
Targeted Allele Detail

Summary

• Symbol: Cacnb2^tm1.1Hfm
• Name: calcium channel, voltage-dependent, beta 2 subunit; targeted mutation 1.1, Franz Hofmann
• MGI ID: MGI:7262904
• Synonyms: BStop
• Gene: Cacnb2 Location: Chr2:14607899-14992719 bp, + strand Genetic Position: Chr2, 10.7 cM
• Alliance: Cacnb2^tm1.1Hfm page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:323278
• Parent Cell Line: R1 (ES Cell)
• Strain of Origin: (129X1/SvJ x 129S1/Sv)F1-Kitl⁺

Mutation description

• Allele Type: Targeted (Not Specified)
• Mutations: Insertion, Nucleotide substitutions
• Mutation details: A floxed pgk-neo and thymidine kinase gene cassette was inserted in intron 13 and exon 14 was replaced with one containing an in-frame stop codon (TGA) after proline 501. Cre mediated recombination removed the neo and thymidine kinase gene cassette.Western blot analysis confirmed the expression of a C-terminal truncated protein. (J:323278)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Cacnb2 Mutation: 48 strains or lines available

References

• Original: J:323278 Brandmayr J, et al., Deletion of the C-terminal phosphorylation sites in the cardiac beta-subunit does not affect the basic beta-adrenergic response of the heart and the Ca(v)1.2 channel. J Biol Chem. 2012 Jun 29;287(27):22584-92
• All: 1 reference(s)