Dek^tm1.1Yhou
Targeted Allele Detail

Summary

• Symbol: Dek^tm1.1Yhou
• Name: DEK proto-oncogene; targeted mutation 1.1, Yu Hou
• MGI ID: MGI:7258390
• Synonyms: Dek^fl
• Gene: Dek Location: Chr13:47238251-47259677 bp, - strand Genetic Position: Chr13, 24.5 cM, cytoband B1
• Alliance: Dek^tm1.1Yhou page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:322182
• Parent Cell Line: Not Specified (ES Cell)
• Strain of Origin: Not Specified

Mutation description

• Allele Type: Targeted (Conditional ready, No functional change)
• Mutation: Insertion
• Mutation details: Exons 3-5 were flanked by loxP sites. An FRT-flanked neomycin gene was inserted before the second loxP site and was removed via flp-mediated recombination (J:322182)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Dek Mutation: 37 strains or lines available

References

• Original: J:322182 Chen Z, et al., Nuclear DEK preserves hematopoietic stem cells potential via NCoR1/HDAC3-Akt1/2-mTOR axis. J Exp Med. 2021 May 3;218(5)
• All: 1 reference(s)