Chrna5^tm1.1Stit
Targeted Allele Detail

Summary

• Symbol: Chrna5^tm1.1Stit
• Name: cholinergic receptor, nicotinic, alpha polypeptide 5; targeted mutation 1.1, Jerry A Stitzel
• MGI ID: MGI:7256726
• Synonyms: alpha5SNP
• Gene: Chrna5 Location: Chr9:54888164-54915063 bp, + strand Genetic Position: Chr9, 29.84 cM
• Alliance: Chrna5^tm1.1Stit page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:256457
• Parent Cell Line: Not Specified (ES Cell)
• Strain of Origin: C57BL/6

Mutation description

• Allele Type: Targeted (Humanized sequence)
• Mutation: Single point mutation
• Mutation details: An aspartic acid codon (GAT) was mutated to an asparagine codon (AAT) at amino acid position 397 (D397N). Cre-mediated recombination removed an intronic neomycin selection cassette. The amino acid position 397 in mice is equivalent to position 398 in human and the D398N variant is associated with reduced resting-state functional connectivity in humans. (J:256457)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Chrna5 Mutation: 40 strains or lines available

References

• Original: J:256457 Koukouli F, et al., Nicotine reverses hypofrontality in animal models of addiction and schizophrenia. Nat Med. 2017 Mar;23(3):347-354
• All: 2 reference(s)