Igs2^{em1(CAG-Ffar4)Jnu}
Endonuclease-mediated Allele Detail

Summary

• Symbol: Igs2^{em1(CAG-Ffar4)Jnu}
• Name: intergenic site 2; endonuclease-mediated mutation 1, Ji'nan University
• MGI ID: MGI:7256542
• Gene: Igs2 Location: Chr11:3195460-3195497 bp Genetic Position: Chr11, Syntenic
• Alliance: Igs2^{em1(CAG-Ffar4)Jnu} page

Mutation origin

• Strain of Origin: C57BL/6J

Mutation description

• Allele Type: Endonuclease-mediated (Inserted expressed sequence)
• Mutation: Insertion
• Igs2^{em1(CAG-Ffar4)Jnu} expresses 1 gene
  Knock-in expresses:
  

  Organism	Expressed Gene	Note
  mouse	Ffar4 (MGI:2147577)

• Mutation details: A CAG promoter, loxP-flanked STOP cassette, Ffar4 cDNA and polyA signal were inserted into the locus vis CRISPR/Cas9 technology. (J:325565)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Igs2 Mutation: 69 strains or lines available

References

• Original: J:325565 Zhu S, et al., Free fatty acid receptor 4 deletion attenuates colitis by modulating Treg Cells via ZBED6-IL33 pathway. EBioMedicine. 2022 Jun;80:104060
• All: 1 reference(s)