Panx1^em1Ravi
Endonuclease-mediated Allele Detail

Summary

• Symbol: Panx1^em1Ravi
• Name: pannexin 1; endonuclease-mediated mutation 1, Kodi S Ravichandran
• MGI ID: MGI:6888006
• Synonyms: Panx1^S205A
• Gene: Panx1 Location: Chr9:14917081-14956774 bp, - strand Genetic Position: Chr9, 4.52 cM
• Alliance: Panx1^em1Ravi page

Mutation origin

• Strain of Origin: C57BL/6 x SJL

Mutation description

• Allele Type: Endonuclease-mediated (Not Specified)
• Mutation: Nucleotide substitutions
• Mutation details: Using an sgRNA (targeting CCACTTCAAGTACCCAATCG) and an ssODN template (GTGAAGAGAGGCTGAAGTAATAGCTCAAGTAGATACATGCCAACAGTATAACCACAAATGTCACCAGCCGGCAGCTAATGTATTTCATGATTAAATGACTCGCGTTCTTTTTTGTCTTCAAGTACTGCTCAACGATTGGGTACTTGAAGTGGCTTTCAGATATCTCCCACAGACTGAAAAACAAAGCAAATAAAAATAAT) with CRISPR/Cas9 technology, serine codon 205 (TCT) was changed to alanine (GCG)(p.S205A). This mutation renders residue 205 non-phosphorylatable. (J:314437)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Panx1 Mutation: 41 strains or lines available

References

• Original: J:314437 Medina CB, et al., Pannexin 1 channels facilitate communication between T cells to restrict the severity of airway inflammation. Immunity. 2021 Aug 10;54(8):1715-1727.e7
• All: 1 reference(s)