Klb^em1Mpot
Endonuclease-mediated Allele Detail

Summary

• Symbol: Klb^em1Mpot
• Name: klotho beta; endonuclease-mediated mutation 1, Matthew J Potthoff
• MGI ID: MGI:6887705
• Synonyms: KLB loxTB
• Gene: Klb Location: Chr5:65505657-65541350 bp, + strand Genetic Position: Chr5, 33.64 cM
• Alliance: Klb^em1Mpot page

Mutation origin

• Strain of Origin: Not Specified

Mutation description

• Allele Type: Endonuclease-mediated (Conditional ready, Null/knockout)
• Mutation: Insertion
• Mutation details: CRISPR/Cas9 technology inserted a floxed transcriptional blocking sequence (an En2 splice acceptor followed by three SV40 poly-A sequences) in the intronic region between exon 1 and exon 2. (J:321589)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Klb Mutation: 57 strains or lines available

References

• Original: J:321589 Flippo KH, et al., FGF21 suppresses alcohol consumption through an amygdalo-striatal circuit. Cell Metab. 2022 Feb 1;34(2):317-328.e6
• All: 1 reference(s)