Pde4d^em1Smoc
Endonuclease-mediated Allele Detail

Summary

• Symbol: Pde4d^em1Smoc
• Name: phosphodiesterase 4D, cAMP specific; endonuclease-mediated mutation 1, Shanghai Model Organisms Center
• MGI ID: MGI:6867256
• Synonyms: Pde4d^{em1(flox)Smoc}, Pde4d^flox, Pde4d-Flox
• Gene: Pde4d Location: Chr13:108790711-110092503 bp, + strand Genetic Position: Chr13, 59.69 cM
• Alliance: Pde4d^em1Smoc page

Mutation origin

• Strain of Origin: C57BL/6JSmoc

Mutation description

• Allele Type: Endonuclease-mediated (Conditional ready)
• Mutation: Insertion
• The allele contains loxP sites flanking target exons of Pde4d gene. (J:238766, J:320016)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 1 strain available Cell Lines: 0 lines available
• Carrying any Pde4d Mutation: 184 strains or lines available

References

• Original: J:320016 Fan T, et al., Phosphodiesterase 4D promotes angiotensin II-induced hypertension in mice via smooth muscle cell contraction. Commun Biol. 2022 Jan 20;5(1):81
• All: 3 reference(s)