Nrg1^tm1.1Lwr
Targeted Allele Detail

Summary

• Symbol: Nrg1^tm1.1Lwr
• Name: neuregulin 1; targeted mutation 1.1, Lorna W Role
• MGI ID: MGI:6854706
• Synonyms: CRD-NRG-1^-
• Gene: Nrg1 Location: Chr8:32299493-33381858 bp, - strand Genetic Position: Chr8, 18.75 cM
• Alliance: Nrg1^tm1.1Lwr page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:101977
• Parent Cell Line: Not Specified (ES Cell)
• Strain of Origin: 129

Mutation description

• Allele Type: Targeted (Null/knockout)
• Mutation: Insertion
• Mutation details: The cysteine-rich domain (CRD) in the alternatively spliced N-terminus was disrupted by the creation of a nonsense mutation and an Xba1 site in the exon encoding the CRD. A loxP site flanked neomycin resistance gene cassette was inserted into the intron following the CRD-encoding exon. Germline, cre-mediated recombination removed the loxP-flanked neomycin cassette. (J:60159)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 1 strain available Cell Lines: 0 lines available
• Carrying any Nrg1 Mutation: 56 strains or lines available

Notes

The version of this allele that contains the neomycin selection cassette, Nrg1^tm1Lrw, has been analyzed.

References

• Original: J:60159 Wolpowitz D, et al., Cysteine-rich domain isoforms of the neuregulin-1 gene are required for maintenance of peripheral synapses. Neuron. 2000 Jan;25(1):79-91
• All: 2 reference(s)