Summary | Mutation origin | Mutation description | Expression | Phenotypes | Find Mice (IMSR) | References

Symbol:	Nrg1tm1Lwr
Name:	neuregulin 1; targeted mutation 1, Lorna W Role
MGI ID:	MGI:1928831
Synonyms:	CRD-NRG-1-, Nrg1Lwrtm1, Nrg1tm1.1Lwr, Type III Nrg1-
Gene:	Nrg1  Location: Chr8:32299493-33381858 bp, - strand  Genetic Position: Chr8, 18.75 cM
Alliance:	Nrg1tm1Lwr page

Germline Transmission:	Earliest citation of germline transmission: J:60159
Parent Cell Line:	Not Specified (ES Cell)
Strain of Origin:	129

Allele Type:    Targeted (Null/knockout) Mutation:    Insertion   Mutation details: The cysteine-rich domain (CRD) in the alternatively spliced N-terminus was disrupted by the creation of a nonsense mutation and an Xba1 site in the exon encoding the CRD. A loxP site flanked neomycin resistance gene cassette was inserted into the intron following the CRD-encoding exon. (J:60159)

View phenotypes and curated references for all genotypes (concatenated display).

In Structures Affected by this Mutation:

11 anatomical structure(s)

Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:	Mouse Strains: 0 strains available      Cell Lines: 0 lines available
Carrying any Nrg1 Mutation:	53 strains or lines available

Original:	J:60159 Wolpowitz D, et al., Cysteine-rich domain isoforms of the neuregulin-1 gene are required for maintenance of peripheral synapses. Neuron. 2000 Jan;25(1):79-91
All:	28 reference(s)