Wnt16^tm1.1Amc
Targeted Allele Detail

Summary

• Symbol: Wnt16^tm1.1Amc
• Name: wingless-type MMTV integration site family, member 16; targeted mutation 1.1, Andrew P McMahon
• MGI ID: MGI:6852751
• Gene: Wnt16 Location: Chr6:22288226-22298521 bp, + strand Genetic Position: Chr6, 9.22 cM, cytoband A3
• Alliance: Wnt16^tm1.1Amc page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:317388
• Parent Cell Line: Not Specified (ES Cell)
• Strain of Origin: Not Specified

Mutation description

• Allele Type: Targeted (Null/knockout)
• Mutations: Insertion, Intragenic deletion
• Mutation details: A loxP site was inserted upstream of exon 2 and an FRT flanked PGK-neo cassette and loxP site were inserted downstream of exon 2 via homologous recombination. Cre mediated recombination removed exon 2 and the neo cassette. (J:317388)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Wnt16 Mutation: 30 strains or lines available

References

• Original: J:317388 Nalesso G, et al., WNT16 antagonises excessive canonical WNT activation and protects cartilage in osteoarthritis. Ann Rheum Dis. 2017 Jan;76(1):218-226
• All: 1 reference(s)