Chrna4^tm4Lst
Targeted Allele Detail

Summary

• Symbol: Chrna4^tm4Lst
• Name: cholinergic receptor, nicotinic, alpha polypeptide 4; targeted mutation 4, Henry Lester
• MGI ID: MGI:6850674
• Synonyms: alpha4-mCherry
• Gene: Chrna4 Location: Chr2:180664104-180685339 bp, - strand Genetic Position: Chr2, 103.54 cM
• Alliance: Chrna4^tm4Lst page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:247489
• Parent Cell Line: CJ7 (ES Cell)
• Strain of Origin: 129S1/Sv-Oca2⁺ Tyr⁺ Kitl⁺

Mutation description

• Allele Type: Targeted (Epitope tag, Reporter)
• Mutation: Insertion
• Mutation details: An mCherry gene with an HA epitope tag at the 5' end was inserted in-frame into exon 5, which encodes the M3-M4 cytoplasmic loop of the encoded protein. This allele expresses a fusion protein under the control of the endogenous gene. (J:247489)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 1 strain available Cell Lines: 0 lines available
• Carrying any Chrna4 Mutation: 42 strains or lines available

References

• Original: J:247489 Srinivasan R, et al., Smoking-Relevant Nicotine Concentration Attenuates the Unfolded Protein Response in Dopaminergic Neurons. J Neurosci. 2016 Jan 06;36(1):65-79
• All: 8 reference(s)