Esco1^tm1.2Ge
Targeted Allele Detail

Summary

• Symbol: Esco1^tm1.2Ge
• Name: establishment of sister chromatid cohesion N-acetyltransferase 1; targeted mutation 1.2, Gregor Eichele
• MGI ID: MGI:6828775
• Gene: Esco1 Location: Chr18:10566507-10610352 bp, - strand Genetic Position: Chr18, 5.21 cM, cytoband A2
• Alliance: Esco1^tm1.2Ge page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:296958
• Parent Cell Line: Not Specified (ES Cell)
• Strain of Origin: 129S2/SvPas

Mutation description

• Allele Type: Targeted (Null/knockout)
• Mutations: Insertion, Intragenic deletion
• Mutation details: The targeting cassette inserted an FRT-flanked neomycin resistance cassette with a 5' loxP site upstream of exon 2. An additional loxP site was inserted downstream of exon 3. Flp-mediated recombination removed the selection cassette. Cre-mediated recombination removed exons 2 and 3. (J:296958)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Esco1 Mutation: 50 strains or lines available

References

• Original: J:296958 Ajam T, et al., Alternative catalytic residues in the active site of Esco acetyltransferases. Sci Rep. 2020 Jun 17;10(1):9828
• All: 1 reference(s)