Amfr^em1Gpt
Endonuclease-mediated Allele Detail

Summary

• Symbol: Amfr^em1Gpt
• Name: autocrine motility factor receptor; endonuclease-mediated mutation 1, GemPharmatech Co., Ltd
• MGI ID: MGI:6771472
• Synonyms: Amfr^em1Cflox, Amfr^fl
• Gene: Amfr Location: Chr8:94698216-94739301 bp, - strand Genetic Position: Chr8, 45.96 cM
• Alliance: Amfr^em1Gpt page

Mutation origin

• Strain of Origin: C57BL/6JGpt

Mutation description

• Allele Type: Endonuclease-mediated (Conditional ready, No functional change)
• Mutation: Insertion
• CRISPR-targeting flanked exons 5 through 9. (J:311437)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Amfr Mutation: 42 strains or lines available

References

• Original: J:311437 Liu SS, et al., The chemokine CCL1 triggers an AMFR-SPRY1 pathway that promotes differentiation of lung fibroblasts into myofibroblasts and drives pulmonary fibrosis. Immunity. 2021 Sep 14;54(9):2042-2056.e8
• All: 1 reference(s)